I know my allergy is genetic, my sister and I both have it, it came from my mothers side, but I have also found some people got it after having an infection or sickness.
I do believe it is genetic. It is an abnormal Immune Response.
Posted Sep 24, 2018 by 6000
Genetics factors for some people with Cold Urticaria. For others it is really unknown but some can link back to a virus or insect bite or other even that seems to trigger the condition. There isn't enough research out there to understand. In my case I really can't idenitfy any one thing, but suspect genetics may play a part.
Genetics and/or infection is the most probable causes. It's unknown why some people get CU after an infection.
There is a known gene mutation that result in CU (The gene is: phospholipase C-gamma2 (PLCG2))
I'm honestly not sure what causes it , my specialist even said she isnt sure its differs from case to case , for some it hereditary, others might have gotten a bug bite or had an illness . My specialist is still stumped by what caused mine
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