Treatment will focus on reducing or managing symptoms.
Depending on the severity of your condition, you may need to manage your condition before or after cold exposure.
Medications like antihistamines can prevent or minimize the release of histamines when exposed to the cold.
Your condition may not respond to antihistamines. It may require another approach.
A 2019 study found that taking 150 to 300 mg of omalizumab (Xolair) every 4 weeks was effective in treating CU that did not respond to antihistamines.
Your doctor may also recommend other medications to treat CU, including:
corticosteroids
synthetic hormones
antibiotics
leukotriene antagonists
other immunosuppressants
You may need to carry injectable epinephrine, for example EpiPen, if you experience severe or life-threatening symptoms, such as anaphylaxis, from cold exposure.