The term "best" is highly subjective and because people are unique in the way they experience the pain of CRPS, their response to treatment varies. Most start with medication including pain drugs, most often opioids (i.e. fentanyl, hydrocodone, oxycodone, etc.), and nerve agents (i.e. gabapentin, Lyrica). Antidepressant medications (i.e. nortriptyline), beta-blockers (i.e., metoprolol), and low dose Naltrexone (which helps with inflammation) have side effects of reducing pain. CBD oil and medical cannabis has been helpful to many with CRPS. Some people find essential oils, cranial-sacral massage, Mindfulness meditation and other alternative therapies to be helpful. Nerve blocks might be attempted at the sight of the pain or in the spine. Spinal cord stimulators and DRG (dorsal root ganglion) stimulators are widely used to interrupt the pain signal to and from the brain. Ketamine infusions and neridronate infusions are frequently used when other treatments are ineffective. Stem cell therapy is not generally helpful for CRPS, but patients often have nerve damage in addition to CRPS, and adult stem cells can be injected at the site with the goal of regenerating nerve cells.