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Any chronic condition can impact relationships...in a family, at work, socially, etc. The way that Lyme manifests itself in some people is debilitating, making it difficult or impossible to function "normally" in one or more facets of life. Friends, families, coworkers and certainly romantic partners may struggle with the resulting limitations but can benefit from and support the Lyme-infected person by learning about the disease and proceeding with compassion and respect.
For new, intimate relationships, I would definitely disclose and discuss it early on. It will undoubtedly interfere with and probably end some of them. Once sexually intimate, I would use protection, indefinitely.