Original
Early diagnosis seems to be key in developing the best treatment plan for children with MIRAGE. Without the diagnosis, it may seem that there are just many random unrelated conditions; diagnosing MIRAGE syndrome draws all of these conditions together under one umbrella and allows the specialists to work cooperatively with one another in their treatment. Premature infants who are small for gestational age and developed in an undersized placenta, and who continue to experience failure to thrive after birth may need to be more closely evaluated, especially if there are ambiguous genitalia. Evaluating for adrenal issues should be standard with children with these symptoms, keeping in mind adrenal insufficiency may not be evident immediately. And testing for the SAMD9 mutation should occur as soon as possible if the child exhibits multiple symptoms of MIRAGE. If the mutation is confirmed, the child should also be monitored on a regular basis for signs of myelodysplasia.