Original
Overactive JAK signaling plays a key role in the pathophysiology of PV.5,6 The JAK2 mutation V617F (or JAK2V617F) is a diagnostic feature of PV and is present in >95% of cases.4
PV affects about 100,000 people in the United States and occurs mostly in older people, with a median age of diagnosis of approximately 60 years.7-9 PV may be slightly more prevalent in men.8