विवरण
Juan Cadiñanos
50 वर्षों
es
en
मेरे बारे में
Soy Dr. en Bioquímica y Biología Molecular por la Universidad de Oviedo. Trabajé como investigador post-doctoral en el Dana-Farber Cancer Institute de Boston y en el Wellcome Trust Sanger Institute de Cambridge entre 2004 y 2008 y, actualmente, dirijo el Laboratorio de Medicina Molecular del Instituto de Medicina Oncológica y Molecular de Asturias (IMOMA) desde su creación (septiembre-2008). Estoy interesando en la investigación y el diagnóstico molecular de las enfermedades con base genética en general, y del cáncer, las sorderas y cegueras en particular.
संपर्क करें
शोधकर्ता आँकड़े
0
सकारात्मक वोट
1122
प्रोफ़ाइल विचार
26
अपलोड किए गए प्रकाशन
5390
पहुंच
55
मैप्स
शिक्षा
Licenciado en Bioquímica. Universidad de Oviedo. 1994-1998
Dr. por la Universidad de Oviedo. Dpto. de Bioquímica y Biología Molecular. Laboratorio del Prof. Carlos López-Otín. 2003
अनुभव
Universidad de Oviedo. Laboratorio del Prof. Carlos López Otín. Oviedo, España. 1998-2003
Investigador predoctoral
Dana Farber Cancer Institute. Universidad de Harvard. Laboratorio del Prof. Ronald DePinho. Boston, USA. 2003-2004.
Investigador postdoctoral
Universidad de Oviedo. Laboratorio del Prof. Carlos López Otín. Oviedo, España. 2004-2006
Investigador postdoctoral
Wellcome Trust Sanger Institute. Laboratorio del Prof. Allan Bradley. Cambridge, UK. 2006-2008
Investigador postdoctoral.
Instituto de Medicina Oncológica y Molecular de Asturias (IMOMA). Oviedo, España. 2008-Actualidad.
Director del Laboratorio de Medicina Molecular.
शोध
- Breast Cancer
- Colon Cancer
- Prostate Cancer
- Melanoma
- Retinitis pigmentosa
- Cowden syndrome
- Bartter's Syndrome
- Charge Syndrome
- Wolfram Syndrome
- Usher Syndrome
- Stickler syndrome
- Marshall syndrome
- Alport Syndrome
- Waardenburgs Syndrome
- Crouzon syndrome
- Palmoplantar Keratoderma
- Jervell And Lange-Nielsen Syndrome
- MELAS Syndrome
- Charcot-Marie-Tooth Disease
- Cone-rod Dystrophies
- Door Syndrome
- Ovarian cancer
- Anal Cancer
- Endometrial cancer
- Stomach cancer
- Pancreatic cancer
- Skin Cancer
- Kidney Cancer
- Thyroid cancer
- Lung cancer
- Stargardt Disease
- Retinopathy Of Prematurity
- X Linked Juvenile Retinoschisis
- Joubert Syndrome
- Leber Hereditary Optic Neuropathy
- Bardet-Biedl Syndrome
- Hypotrichosis with Juvenile Macular Degeneration
- Choroideremia
- Achromatopsia
- Coats Disease
- Kallmann Syndrome
- Oculo-Dento-Digital Dysplasia
- Hurler Syndrome MPS1H
- Mainzer-Saldino syndrome
- Alagille Syndrome
- Best Vitelliform Macular Dystrophy
- Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS)
- Norrie Disease
- Optic Nerve Hypoplasia
- Aicardi Syndrome
- Cohen Syndrome
- Lynch Syndrome
- Liver Cancer
- Progeria
- Pheochromocytoma
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यह शोधकर्ता अभी तक किसी भी मैप में नहीं है
प्रश्न उत्तर दिए
प्रकाशन
- Elucidating the clinical significance of two PMS2 missense variants coexisting in a family fulfilling hereditary cancer criteria. - lynch-syndrome - https://www.ncbi.nlm.nih.gov/pubmed/28365877
- A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes. - prostate-cancer - https://www.ncbi.nlm.nih.gov/pubmed/28319090
- Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice. - pancreatic-cancer - https://www.ncbi.nlm.nih.gov/pubmed/28079877
- CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice. - liver-cancer - https://www.ncbi.nlm.nih.gov/pubmed/26508638
- A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer. - pancreatic-cancer - https://www.ncbi.nlm.nih.gov/pubmed/25485836
- Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion. - lung-cancer - https://www.ncbi.nlm.nih.gov/pubmed/23917225
- A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. - colon-cancer - https://www.ncbi.nlm.nih.gov/pubmed/23845441
- Refining the role of PMS2 in Lynch syndrome: germline mutational analysis improved by comprehensive assessment of variants. - lynch-syndrome - https://www.ncbi.nlm.nih.gov/pubmed/23709753
- Novel germline CDKN2A mutation associated with head and neck squamous cell carcinomas and melanomas. - melanoma - https://www.ncbi.nlm.nih.gov/pubmed/22083977
- Splicing-directed therapy in a new mouse model of human accelerated aging. - pyelonephritis - https://www.ncbi.nlm.nih.gov/pubmed/22030750
- Néstor-Guillermo progeria syndrome: a novel premature aging condition with early onset and chronic development caused by BANF1 mutations. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/21932319
- Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/21549337
- Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/21522133
- Type B mandibuloacral dysplasia with congenital myopathy due to homozygous ZMPSTE24 missense mutation. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/21267004
- Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/21113150
- PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mic - acute-myelogenous-leukemia - https://www.ncbi.nlm.nih.gov/pubmed/20947725
- Novel germline SDHD deletion associated with an unusual sympathetic head and neck paraganglioma. - pheochromocytoma - https://www.ncbi.nlm.nih.gov/pubmed/20310044
- Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/18587406
- Premature aging in mice activates a systemic metabolic response involving autophagy induction. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/18443001
- Nuclear envelope defects cause stem cell dysfunction in premature-aging mice. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/18378773
- Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/17131053
- From immature lamin to premature aging: molecular pathways and therapeutic opportunities. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/16258283
- Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/16079796
- Genomic instability in laminopathy-based premature aging. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/15980864
- Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/15843403
- Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. - progeria - https://www.ncbi.nlm.nih.gov/pubmed/11923874