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Depends on the type of work and the level of pain.
Sitting jobs are the worse, as the pain and stiffness get worse after longer periods of no (or minimum) physical activity.
Some useful tips:
http://www.everydayhealth.com/arthritis/on-the-job-with-ankylosing-spondylitis.aspx
https://www.quora.com/What-careers-are-most-suitable-for-people-who-have-Ankylosing-Spondylitis