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A study done by Mayo Clinic in 2003 reviewed records from 1989-1999 and found an incidence rate of 5.46 per 100,000 person. A Dutch study placed the incidence rate at 26.2 per 100,000. The lack of prevalence of registered patients may underestimate the true prevalence of CRPS by 50%.
Female:male ratio was 4:1, with a median age of 46 years at onset.
Upper limb was affected twice as commonly as lower limb. All cases reported an antecedent event and fracture was the most common trigger (46%).
The National Institutes of Health have estimated that 2-5% of people who have a peripheral nerve injury (such as a sprain or fracture, bullet wound, cut or needle stick) will develop CRPS.