元の
The 6 genes involved have so far been classed into 4 main types of HH. The researchers now agree on a classification into Type 1-5. It is also recognized that Ferritin should be as low as 50 or even lower to keep the Transferrin Saturation below 45-50 %. Some countries have started to do phlebotomies looking more at Transferrin Saturation than the level of Ferritin. Researchers may now be on track of the "unknown factors" which may be contributing to the fact that some accumulate a lot of iron much faster than others (all other factors the same) and that some seems to develop damages/diseases and others seems to be almost unaffected. Mutations on the BMP6 gene are suspected to have a role in this.