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Lyme disease is properly diagnosed with blood tests. The patient's blood must be sent to one of only a few labs nationwide that is sensitive enough to give accurate results. Many labs do not give accurate results > false positives or false negatives. Lyme-literate physicians (LLMD) know which labs to send the blood to.
Also, my Lyme-literate physician who diagnosed me after spending 7 years without a diagnosis made a "clinical diagnosis" within 15 minutes of me stepping into his office for the first time. Seven years and many, many doctors who had no clue what was wrong with me. A physician at Stanford University Hospital said to me, "Western medicine is not equipped to find all that is wrong in the body and you are one of those who is slipping through the cracks."
The one symptom upon which my LLMD made his clinical diagnosis was based on the fact that my eyes were ultra-sensitive to light and teared up in sunlight (tears running down my face, even with dark sunglasses on). This symptom does not cross over with other diseases.
After diagnosis, find an alternative-oriented MD who has an Integrative Medicine practice. Also, many of us are helped by a variety of treatments for symptoms: Osteopathic treatment, acupuncture, therapeutic massage, homeopathic treatment, etc.
"The most common diagnostic tests for Lyme disease are indirect ones. They measure the patient's antibody response to the infection, not the infection itself. The two most-used antibody tests are the enzyme-linked immunosorbent assay (ELISA) and the Western blot." - source, LymeDisease.org