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Researchers are looking for genes that might increase a person’s risk of developing PSP. Scientists are studying gene-environment interaction – in which environmental factors and genetics may contribute to disease susceptibility for many diseases in which there may be genetic influences that differ among families or even in a single family. Investigators are integrating research tools involved with human genetics and disease epidemiology to better understand the joint risk factors that may contribute to the cause of PSP.
Recent approaches to therapeutic development for PSP have focused primarily on the clearance of abnormally accumulated tau in the brain. One ongoing clinical trial will determine the safety and tolerability of a compound that prevents accumulation of tau in preclinical models. Other studies are exploring improved tau imaging agents that will be used to assess disease progression and improvement in response to treatment.