For kids with Systemic Juvenile Idiopathic Arthritis, everyone is affected at different degrees and may not respond to the same medications as others. For most, SJIA is treated with a steroid called Prednisone and one or more biologics like Kineret, Ilaris, Humira, Orencia, and Methotrexate. Some children may be treated with Actemra, which is infused into the body through an IV over the course of 2-3 hours every two weeks.