The disease can last for a considerably long time. Occasionally, "spontaneous cure" may ensue,[43] particularly in young girls.
Lichen sclerosus is associated with a higher risk of cancer.[44][45][46] Skin that has been scarred as a result of lichen sclerosus is more likely to develop skin cancer. Women with lichen sclerosus may develop vulvar carcinoma.[47] Lichen sclerosus is associated with 3–7% of all cases of vulvar squamous cell carcinoma.[48] In women, it has been reported that 33.6 times higher vulvar cancer risk is associated with LS.[49] A study in men reported that "The reported incidence of penile carcinoma in patients with BXO is 2.6–5.8%".[50]