Orginalny
The Most Visible Lesion: The Eye
Diagnosing congenital PLGD typically begins very early in life because of the appearance of ligneous conjunctivitis, a hallmark symptom of plasminogen deficiency. These fibrin-rich, woody-like (ligneous) lesions in the membranes of the eye usually form during childhood. They are the most common of its identifiable symptoms, occurring in four out of five cases. Appearing as thick yellow, white, or red lesions on the inside of the eyelids, ligneous conjunctivitis is a common symptom of PLGD. If left untreated, the cornea may be damaged and result in vision loss.
Systemic Lesions Elsewhere in the Body
Since multiple systems can be affected, examination of the mouth, ears, throat, respiratory tract, and female genital tract should also be done to see if the lesions occur in other areas. Ligneous lesions may arise on any number of mucosal membrane surfaces throughout the body. Examining a child’s sun-exposed skin may show juvenile colloid milium a rare skin condition associated with congenital PLGD.