Orginalny
It varies depending on the disease variant. For patients with more severe diffuse forms of scleroderma, it can be severe pain and fatigue, physical deformity (typically hands then face). Digital ulcers can be very painful and slow healing, potentially leading to gangrene and auto-amputations. Lung problems are common in this disease and are currently the leading cause of death. While the disease gets its name from hardening of the skin, in the limited variants of the disease, this symptom is often delayed for many years. In the diffuse variants, skin changes are usually very common in early years.