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1. Lack of head control
2. Central hypotonia combined in most cases with peripheral hypertonia
3. Mental retardation
4. Gaining and maintaining weight
5. Constipation
6. Increased heart rate
7. Motor delay
8. Low bone density
9. Epileptic seizures
10. Delayed Myelination or hypomyelination
11. Sleep problems/associated anxiety
12. Problems swallowing/inhaling food
13. Dystonia
14. Heartburn and gastroesophageal reflux disease also known as GORD or Acid reflux
15. Stomach cramps/ digestive problems
16. Excess drooling
17. Low Immune system