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I have yet to speak with 2 people who are affected in exactly the same way, or to the same severity and so there is no definitive answer to this question.
I worked as an office administrator for a few years before my CED began to affect my arms. This meant that jobs I had been doing previously (typing, filing, etc) became too painful and I personally decided that by trying to work, even part-time, I was doing myself more harm than good and I resigned.
However, it is up to the individual as to whether they feel capable of working or not.