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CRPS generally starts in a limb, limiting its use as the disease progresses. 75% of the time the disease will spread to other parts of the body. With mild to moderate CRPS, most people are able to work as long as that work does not require use of the affected limb. In more severe cases, excruciating pain and fatigue limit the ability to work. CRPS is considered a rare disease, so numbers of people working in specific fields are limited.