Какова история Алкаптонурия?

Когда Алкаптонурия была открыта? Какова история этого открытия? Это было случайностью или нет?

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Alcapton was Used to describe a persons urinary compound in 1897, later identified as Homogentisic acid, by 1908 Archibald Garrod has suggested that Alkaptonuria was an inborn error of metabolism. Because it was a very rare nothing has actually been done about this"black bone"/ black urine disease.

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