Оригинал
The worst symptoms largely (but not definitively) depend upon the particular subtype of EDS you are diagnosed with. While hypermobility and associated chronic pain and daily headaches are common across the subtypes, there are also a number of neurological conditions which crossover. These co-morbid conditions include Cranio Cervical Instability, Chiari Malformations and Idiopathic Intracranial Hypertension.
The symptoms of these conditions can be debilitating. Chronic Fatigue is perhaps the 'worst' symptom in as much as it can be completely debilitating and severely limiting quality of life. Many EDS sufferers experience chronic fatigue without any diagnosis (or investigation) of comorbid neurological conditions and it is generally considered to be a symptom of EDS.
In addition, many with EDS suffer with POTS (Postural Orthostatic Intolerance) which some consider the worst symptom (subject to the intensity and frequency experienced).
The reality is that there is no way to give a comprehensive response to this question given the highly subjective and individualised nature of symptoms that differ from individual to individual.