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What are the best treatments for Adrenal Cortical Carcinoma (ACC)?
Treatments for Adrenal Cortical Carcinoma (ACC): what real patients say works for them, alongside a medically reviewed overview citing sources like NIH GARD and Orphanet.
There us no "best" treatment since ACC has so many unknonws. The standard treatment is mitotane and the standard IV chemo is the Italian method.
Posted Jun 11, 2017 by Grace 500
Open abdominal surgery by a surgeon experienced in ACC is the best treatment available. This would be recommended for patients presenting with stage 1, 2 or 3 ACC. Note that a diagnosis of ACC is not made until after the mass and any involved organs are surgically removed. Biopsies are never recommended for ACC.
For stage 4 patients where the cancer has metastasized to other organs, the treatment of choice is a combination of the drug Mitotane plus intravenous chemotherapy consisting of etoposide, doxorubicin (also called adriamycin) and cisplatin. The goal is usually to shrink the cancer enough to make surgery possible.
For those where the cancer has spread on the surfaces of abdominal organs, a procedure that combines both abdominal surgery and a procedure called HIPEC (heated intraperitoneal chemotherapy). HIPEC is a warmed and concentrated solution of cisplatin that is used to bathe the entire abdomen for approximately 90 to 120 minutes following surgical removal of all visible cancer. The drug comes into direct contact with microscopic remnants of cancer cells and kills them. The abdomen is then flushed to remove the chemotherapeutic agent, and a drug is given intravenously to prevent systemic effects and preserve kidney function.
Surgery is currently the only known cure for ACC. There are other techniques that are effective and include: radio frequency ablation, chemo-emobolization and low dose or stereotactic radiation. The first two are generally used to treat liver metastases. Low dose radiation is sometimes warranted when surgical margins are not clean; radiation is used to treat the surgical bed with variable results concerning recurrence. Stereotactic radiation can be used on metastases generally 0.5 to 2.0 cm and is most often used to treat metastases in the lungs.
For stage 4 patients where the cancer has metastasized to other organs, the treatment of choice is a combination of the drug Mitotane plus intravenous chemotherapy consisting of etoposide, doxorubicin (also called adriamycin) and cisplatin. The goal is usually to shrink the cancer enough to make surgery possible.
For those where the cancer has spread on the surfaces of abdominal organs, a procedure that combines both abdominal surgery and a procedure called HIPEC (heated intraperitoneal chemotherapy). HIPEC is a warmed and concentrated solution of cisplatin that is used to bathe the entire abdomen for approximately 90 to 120 minutes following surgical removal of all visible cancer. The drug comes into direct contact with microscopic remnants of cancer cells and kills them. The abdomen is then flushed to remove the chemotherapeutic agent, and a drug is given intravenously to prevent systemic effects and preserve kidney function.
Surgery is currently the only known cure for ACC. There are other techniques that are effective and include: radio frequency ablation, chemo-emobolization and low dose or stereotactic radiation. The first two are generally used to treat liver metastases. Low dose radiation is sometimes warranted when surgical margins are not clean; radiation is used to treat the surgical bed with variable results concerning recurrence. Stereotactic radiation can be used on metastases generally 0.5 to 2.0 cm and is most often used to treat metastases in the lungs.
Posted Jun 11, 2017 by Sherry 200
The best treatment is open surgery to remove all the cancer.
Posted Mar 9, 2018 by Accmom 2500
Mitotane therapy is my current treatment.
Posted May 22, 2018 by Kim 1600
Lysodren
Chimiothérapie cisplatine et etoposide
Chirurgie de la tumeur
Chimiothérapie cisplatine et etoposide
Chirurgie de la tumeur
Posted Feb 26, 2019 by Flor 400
