Well it seems that a lot of people suffering from AS do also suffers from a form of depression.
Though I am not sure that without AS their depression will be gone... But of course dealing with AS is tough!
It is a chronic illness and a painful one. So there is no doubt it has an influence on the mood.
Lack of sleep, chronic pain, reduced capabilities, are all factors that can be hard to cop with.
Then the social aspect is also a difficult thing to deal with as a lot of people are unaware about what AS means. It also request to sometimes say no to some people although we really want to spent some time with them, or to cancel an event or activity at the last moment... all this can become hard to understand for some people and can lead to a lot of misunderstanding. This can have a huge impact too in someone affected by AS.