Also, called Bechterews disease among many others, Ankylosing Spondylitis is thought to have been identified in 1559, by Realdo Columbo and the first pathological changes were documented in 1691, by Bernard Connor.
The first book was published, by David Tucker in 1858. It detailed the case of Leonard Trask, which was the first known case in the USA.
The first x rays identifying AS were taken in 1897.
Aortic incompetence was associated with AS in 1956.
HLA b27 was discovered in 1973.