I would say arthrogryposis does not directly cause depression on its own, but it can absolutely contribute to it. The hardest part is often not just the physical side, but the emotional weight of pain, fatigue, limited independence, frustration, feeling different, dealing with barriers, and sometimes feeling misunderstood or isolated. All of that can wear on a person’s mood over time. So yes, it can affect mental health, especially if someone is struggling with constant stress, low confidence, loneliness, or the feeling that everyday life takes more effort than it does for other people.