Congenital Insensitivity To Pain With Anhidrosis (CIPA) synonyms

Congenital Insensitivity to Pain with Anhidrosis (CIPA), also known as Hereditary Sensory and Autonomic Neuropathy type IV (HSAN IV), is a rare genetic disorder characterized by the inability to feel pain, temperature, and the absence of sweating. Because it has been studied under various clinical frameworks over several decades, it is frequently referenced by multiple synonyms in medical literature and diagnostic databases.

What are the primary names and synonyms for CIPA?

Medical professionals most commonly use the term Congenital Insensitivity to Pain with Anhidrosis (CIPA). However, because it is a specific subtype of a larger group of disorders, you may encounter it under several alternative labels:

• Hereditary Sensory and Autonomic Neuropathy type IV (HSAN IV): The classification used in formal neurological taxonomies.


• Congenital Analgesia with Anhidrosis: A descriptive term often found in older clinical texts.


• Familial Dysautonomia with Anhidrosis: Sometimes used in historical records, though this is now considered imprecise.


• NTRK1-related sensory neuropathy: A modern term based on the specific genetic mutation identified in the NTRK1 gene.

Why does this condition have so many different names?

The variety of names for Congenital Insensitivity to Pain with Anhidrosis (CIPA) stems from the evolution of medical classification. Early physicians named the condition based solely on observable physical symptoms (pain insensitivity and lack of sweating). As genetic science advanced, the disease was reclassified into the HSAN (Hereditary Sensory and Autonomic Neuropathy) spectrum to better reflect its underlying neurological cause. Today, CIPA is the preferred clinical shorthand, while HSAN IV remains the standard for formal genetic and neurological documentation.

How is CIPA classified in major medical databases?

Standardized databases use specific codes to ensure consistency in medical records. If you are searching for research on Congenital Insensitivity to Pain with Anhidrosis (CIPA), note the following identifiers:

1. OMIM (Online Mendelian Inheritance in Man): #256800


2. Orphanet: ORPHA655


3. ICD-10/11: Often categorized under G60.8 (Hereditary sensory and autonomic neuropathy)

For the 6 community members at DiseaseMaps.org living with Congenital Insensitivity to Pain with Anhidrosis (CIPA), recognizing these synonyms is vital for navigating international medical research and clinical trials.

Next steps

• Consult a neurologist or a clinical geneticist to confirm your specific subtype classification.


• Use the term "HSAN IV" when searching academic databases like PubMed for the most recent clinical literature.


• Connect with the 6 other community members on DiseaseMaps.org to share insights on managing daily care.

Medical disclaimer: This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment; always seek the guidance of a qualified healthcare provider.

References

• NIH Genetic and Rare Diseases Information Center (GARD): CIPA entry.


• Online Mendelian Inheritance in Man (OMIM): #256800.


• Orphanet: Rare Disease Database (ORPHA655).