ICD10 code of Empty Sella Syndrome and ICD9 code

Empty Sella Syndrome is classified under ICD-10 code E23.6 (Other disorders of pituitary gland) and was historically categorized under ICD-9 code 253.8 (Other disorders of the pituitary and related organs). These diagnostic codes are used by clinicians to document the condition, which occurs when the sella turcica—the bony structure protecting the pituitary gland—appears empty or flattened on imaging studies.

What is Empty Sella Syndrome and how is it classified?

Empty Sella Syndrome occurs when the subarachnoid space extends into the sella turcica, causing the pituitary gland to be compressed against the bony walls. While many individuals with Empty Sella Syndrome remain asymptomatic, others may experience hormonal imbalances or vision changes. Because the condition represents a structural finding rather than a single specific disease process, ICD-10 code E23.6 is the standard administrative identifier for Empty Sella Syndrome.

How is Empty Sella Syndrome diagnosed?

Diagnosis of Empty Sella Syndrome is almost always incidental, typically discovered during a brain MRI or CT scan performed for unrelated concerns like headaches. A specialist will evaluate the patient to determine if the Empty Sella Syndrome is "primary" (idiopathic) or "secondary" (resulting from injury, surgery, or radiation). Clinical evaluation usually includes:

• Endocrine blood panels to assess pituitary hormone function (e.g., prolactin, TSH, cortisol).


• Ophthalmological exams to check for visual field defects caused by compression.


• Review of cerebrospinal fluid (CSF) pressure, as high pressure is often associated with the condition.

Is Empty Sella Syndrome common?

Research suggests that primary Empty Sella Syndrome is found in approximately 5% to 20% of the general population during autopsy studies, though most remain undiagnosed. Within our DiseaseMaps community, 15 people with Empty Sella Syndrome have shared their experiences, highlighting the importance of peer support for those navigating the diagnostic process. While often benign, the condition requires monitoring if hormonal deficiencies develop.

Next steps

• Consult an endocrinologist to rule out pituitary hormone deficiencies.


• Schedule an ophthalmology consultation if you experience changes in vision.


• Join the DiseaseMaps community to connect with other patients sharing their journey with Empty Sella Syndrome.


• Keep a detailed log of symptoms, especially headaches or vision shifts, for your specialist.

Medical disclaimer: This content is for informational purposes only and does not constitute professional medical advice, diagnosis, or treatment; always seek the advice of your physician or qualified health provider.

References

• NIH Genetic and Rare Diseases Information Center (GARD): Empty Sella Syndrome.


• Orphanet: Primary empty sella syndrome (ORPHA:99986).


• OMIM (Online Mendelian Inheritance in Man): Entry #601830.


• The Pituitary Foundation: Guidance on pituitary conditions and anatomy.