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In my case, the worse symptom was loss of fine motor skills. My handwriting had become completely illegible, I was no longer able to play the flute (I was the flute section leader in my band). With medication, I have regained much of my fine motor skills. It still takes me a bit longer to write legibly but I can do it.
Another pretty bad symptom was emotional outburst. Every now and then my family would get on my nerves and for some reason I would overreact and become extremely angry. For lack of better terminology, I was seeing red and lost control. Thankfully I managed to maintain enough control that I never hurt anyone while in this state. Again, medication for Wilson's Disease has helped reduce the number of emotional outburst I have. However, this may also be because I have developed some helpful coping mechanisms.