Is Familial Adenomatous Polyposis contagious?

Familial Adenomatous Polyposis (FAP) is not contagious and cannot be spread through touch, proximity, or any form of social contact. It is a strictly genetic condition caused by an inherited mutation, meaning it is biologically impossible to "catch" it from another person.

What is the underlying cause of Familial Adenomatous Polyposis?

Familial Adenomatous Polyposis is an inherited disorder characterized by the development of hundreds to thousands of precancerous polyps in the colon and rectum. The condition is caused by a germline mutation in the APC (adenomatous polyposis coli) gene. Because it is a genetic condition, it is passed from parent to child through families, rather than being caused by viruses, bacteria, or environmental pathogens.

Why is there confusion regarding the contagiousness of Familial Adenomatous Polyposis?

Confusion often arises because Familial Adenomatous Polyposis involves chronic health management and, in some cases, surgery. Because people may see a family member undergoing frequent medical screenings or procedures, they may incorrectly assume the condition is an infectious disease. It is vital to clarify that Familial Adenomatous Polyposis carries no risk of transmission to partners, children, or friends through casual contact, sharing meals, or living in the same household.

Is Familial Adenomatous Polyposis hereditary?

Yes, Familial Adenomatous Polyposis follows an autosomal dominant inheritance pattern. This means an individual with the mutation has a 50% chance of passing it to each of their children. Understanding the genetic nature of Familial Adenomatous Polyposis is key to removing the stigma that patients sometimes face. Key facts include:

• It is caused by a mutation in the APC gene located on chromosome 5q21.


• Approximately 25-30% of cases arise from a "de novo" (new) mutation in the patient, meaning neither parent carried the gene.


• There are no environmental triggers—such as diet or lifestyle—that cause the disease, though they may influence the progression of polyp growth.

Next steps

• Consult a genetic counselor to discuss family testing and screening protocols.


• Schedule regular colonoscopic surveillance with a gastroenterologist specializing in Familial Adenomatous Polyposis.


• Join the 147 members of the DiseaseMaps.org community to share experiences and find emotional support.

Medical disclaimer: This content is for informational purposes only and does not constitute medical advice, diagnosis, or treatment; always seek the advice of a qualified physician with any questions regarding a medical condition.

References

• NIH Genetic and Rare Diseases Information Center (GARD): Familial Adenomatous Polyposis


• Orphanet: Familial Adenomatous Polyposis (ORPHA:734)


• Online Mendelian Inheritance in Man (OMIM): #175100


• The Polyposis Registry at St. Mark's Hospital