Short answer · Medically reviewed summary · Last updated: 2026-04-07
Glanzmanns thrombasthenia is classified under the ICD-10-CM code D69.1 (Qualitative platelet defects), while its corresponding ICD-9-CM code is 287.1 (Qualitative platelet defects). These codes are used by healthcare providers and insurance systems to accurately identify and track this rare inherited bleeding disorder in medical records. What is the clinical nature of Glanzmanns thrombasthenia? Glanzmanns thrombasthenia is a rare, autosomal recessive bleeding disorder characterized by the inability of platelets to aggregate properly.
ICD10 code of Glanzmanns thrombasthenia and ICD9 code
ICD-10 and ICD-9 codes for Glanzmanns thrombasthenia, with classification details for clinicians, coders and patients.
Glanzmanns thrombasthenia is classified under the ICD-10-CM code D69.1 (Qualitative platelet defects), while its corresponding ICD-9-CM code is 287.1 (Qualitative platelet defects). These codes are used by healthcare providers and insurance systems to accurately identify and track this rare inherited bleeding disorder in medical records.
What is the clinical nature of Glanzmanns thrombasthenia?
Glanzmanns thrombasthenia is a rare, autosomal recessive bleeding disorder characterized by the inability of platelets to aggregate properly. This occurs due to a deficiency or dysfunction of the glycoprotein IIb/IIIa (GPIIb/IIIa) receptor complex on the platelet surface. Because platelets cannot bind to fibrinogen, the primary mechanism for forming a stable blood clot is impaired. Patients with Glanzmanns thrombasthenia typically present with lifelong mucocutaneous bleeding, such as frequent nosebleeds (epistaxis), bleeding gums, and easy bruising, which often begin in early childhood.
How is Glanzmanns thrombasthenia diagnosed and classified?
Diagnosis usually involves specialized laboratory testing, including light transmission aggregometry, which consistently shows absent platelet aggregation in response to physiological agonists like ADP, collagen, and epinephrine. Genetic testing is often performed to identify mutations in the ITGA2B or ITGB3 genes, which confirm the diagnosis of Glanzmanns thrombasthenia. While ICD-10 code D69.1 is the primary designation, clinicians categorize the severity of the disease based on the level of GPIIb/IIIa expression: Type I (less than 5% expression), Type II (5–20% expression), and Type III (variant form with non-functional receptors).
Is Glanzmanns thrombasthenia hereditary?
Yes, Glanzmanns thrombasthenia is an inherited condition passed down in an autosomal recessive pattern. This means that an affected individual must inherit two mutated copies of the gene—one from each carrier parent. Because it is a rare genetic condition, the prevalence is estimated to be approximately 1 in 1,000,000 individuals worldwide, though it is more common in populations with a higher rate of consanguineous marriages. At DiseaseMaps.org, we have seen 59 people with Glanzmanns thrombasthenia join our community to share their personal experiences and management strategies.
What are the primary management strategies for patients?
Management focuses on preventing and treating bleeding episodes, as there is currently no curative therapy for Glanzmanns thrombasthenia other than hematopoietic stem cell transplantation in very severe cases. Clinical strategies include:
- Antifibrinolytic agents: Medications like tranexamic acid or aminocaproic acid, often used for dental procedures or mucosal bleeding.
- Recombinant Factor VIIa: Used to manage severe bleeding or as prophylaxis prior to invasive surgeries.
- Platelet transfusions: Reserved for life-threatening bleeding, as repeated transfusions can lead to the development of anti-GPIIb/IIIa antibodies, rendering future transfusions less effective.
- Avoidance of NSAIDs: Patients must strictly avoid aspirin and other non-steroidal anti-inflammatory drugs, as these further inhibit platelet function.
Next steps
- Consult a hematologist who specializes in rare inherited bleeding disorders for a personalized care plan.
- Carry a medical alert identification card or wear a bracelet stating your diagnosis of Glanzmanns thrombasthenia.
- Connect with the 59 members of the DiseaseMaps.org community to exchange tips on managing daily life with this condition.
- Review updated clinical trial information on ClinicalTrials.gov if you are seeking information on emerging therapies.
Medical disclaimer: This information is for educational purposes only and does not replace professional medical advice, diagnosis, or treatment; always seek the advice of your physician or other qualified health provider.
References
- Orphanet: Glanzmann thrombasthenia (ORPHA:837)
- NIH GARD: Genetic and Rare Diseases Information Center: Glanzmann thrombasthenia
- OMIM: Online Mendelian Inheritance in Man: Thrombasthenia of Glanzmann and Naegeli
- World Federation of Hemophilia: Resources on Platelet Function Disorders
