Extreme tiredness, joint pains, Osteoarthritis, Chondrocalcinosis, Osteporosis, loss of libido, pancreas problems which lead to Diabetes Mellitus, Gonadal failure, Hypogonadism, erectile dysfunctions, heart problems, arrhytmia or irregular heartbeat, breathlessness when more active than usual, swelling in legs, ankles and feet, liver problems, cirrhosis, liver cancer, depressions and mood swings, brain fog, +++