Short answer · Medically reviewed summary · Last updated: 2026-04-07

The primary ICD-10-CM code for histoplasmosis is B39, which encompasses various forms of the infection, while the historical ICD-9-CM code is 115. These codes are used by healthcare providers to classify and document Histoplasmosis for medical records, billing, and public health reporting. What is the clinical classification of Histoplasmosis? Histoplasmosis is a systemic fungal infection caused by the inhalation of spores from the fungus Histoplasma capsulatum.

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ICD10 code of Histoplasmosis and ICD9 code

ICD-10 and ICD-9 codes for Histoplasmosis, with classification details for clinicians, coders and patients.

ICD9 and ICD10 codes of Histoplasmosis

The primary ICD-10-CM code for histoplasmosis is B39, which encompasses various forms of the infection, while the historical ICD-9-CM code is 115. These codes are used by healthcare providers to classify and document Histoplasmosis for medical records, billing, and public health reporting.



What is the clinical classification of Histoplasmosis?


Histoplasmosis is a systemic fungal infection caused by the inhalation of spores from the fungus Histoplasma capsulatum. Clinically, the disease is categorized based on the site of infection and the patient's immune status. Under the ICD-10 system, Histoplasmosis is further sub-classified to specify the presentation, such as B39.0 for acute pulmonary Histoplasmosis, B39.1 for chronic pulmonary Histoplasmosis, and B39.2 for acute disseminated Histoplasmosis. These codes allow clinicians to distinguish between localized respiratory involvement and systemic disease that may affect other organ systems.



How is Histoplasmosis diagnosed and coded?


Diagnosis of Histoplasmosis typically involves a combination of clinical assessment, exposure history (often linked to soil enriched with bird or bat droppings), and laboratory testing. Physicians often utilize antigen testing, fungal cultures, and serology to confirm the presence of the pathogen. Once a diagnosis is reached, the appropriate ICD-10 code is assigned to the patient's medical file to ensure accurate tracking. Accurate coding is essential for patients, as it helps insurance providers and public health agencies understand the prevalence of Histoplasmosis across different regions.



What are the key diagnostic markers for Histoplasmosis?


When identifying Histoplasmosis, medical professionals look for specific clinical and laboratory indicators. The following list highlights common diagnostic criteria used to confirm the infection:



  • Antigen Detection: Detecting Histoplasma antigen in urine or serum, which is highly sensitive for disseminated or acute pulmonary cases.

  • Fungal Culture: Growth of the fungus from sputum, bronchoalveolar lavage fluid, or tissue biopsy, which remains the gold standard for diagnosis.

  • Serology: Testing for antibodies (immunodiffusion or complement fixation) to determine past or present exposure.

  • Histopathology: Identifying yeast cells within tissue samples using specialized stains like Grocott-Gomori methenamine silver (GMS).

  • Imaging: Chest X-rays or CT scans showing pulmonary nodules, infiltrates, or mediastinal lymphadenopathy.



Supporting the community


At DiseaseMaps.org, we recognize that living with a diagnosis can be challenging. Currently, 18 people with Histoplasmosis have joined our community to share their experiences and insights. Connecting with others who have navigated the diagnostic process and treatment journey can provide significant emotional support and practical knowledge for those newly diagnosed or dealing with chronic symptoms.



Next steps



  • Consult an infectious disease specialist if you suspect you have been exposed to Histoplasma capsulatum, especially if you reside in the Ohio or Mississippi River valleys.

  • Ensure your medical records are updated with the correct ICD-10 code to facilitate proper insurance coverage and treatment planning.

  • Join the DiseaseMaps.org community for Histoplasmosis to connect with peers and access shared resources.

  • Maintain regular follow-up appointments, as some forms of the disease may require long-term antifungal therapy.



Medical disclaimer: This information is for educational purposes only and does not constitute professional medical advice, diagnosis, or treatment; always seek the advice of your physician or other qualified health provider with any questions regarding a medical condition.



References



  • Centers for Disease Control and Prevention (CDC): Histoplasmosis Statistics and Clinical Guidelines.

  • World Health Organization (WHO): International Classification of Diseases, 10th Revision (ICD-10).

  • NIH Genetic and Rare Diseases Information Center (GARD): Information on Fungal Infections.

  • PubMed Central: "Diagnosis and Management of Histoplasmosis" (Clinical Review).

Medical disclaimer: This information does not substitute professional medical advice. Always consult your doctor before making health decisions.
Source: DiseaseMaps.org
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