Common symptoms include severe fatigue, nausea, chronic pain/joint pain, insomnia, adrenal crisis, adrenal fatigue, diabetes insipidus, compromised immune system, septo-optic dysplasia/optic nerve hypoplasia, hypoglycemia, anxiety, depression, Growth hormone insufficiency, adrenal insufficiency, hypothyroidism, weight gain/loss, abdominal pain/constipation/diarrhea, infertility, low sex drive, sensitivity to cold, short stature/Pituitary dwarfism, lack of menstrual periods, irritability, lack of normal body hair, and other developmental lags and differences.