Tay-Sachs Disease is a genetic disease which comes from a mutation, because of this any celebrity with this would have to be below the age of 5 because the disease will generally kill by then. This is because Tay-Sachs disease destroys nerve cells in the brain and spinal cord. In the end you will generally die as the disease shuts down the nervous system and kills you. Plus no person with this disease would be a celebrity because this disease has many symtoms as reduced mobility and blindness. There is also no cure.