Short answer · Medically reviewed summary · Last updated: 2023-07-13

ACTH deficiency is a relatively rare condition characterized by the inadequate production or release of adrenocorticotropic hormone (ACTH) by the pituitary gland. ACTH is responsible for stimulating the production and release of cortisol from the adrenal glands, which plays a crucial role in regulating various bodily functions. The prevalence of ACTH deficiency varies depending on the population studied and the underlying causes.

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What is the prevalence of ACTH Deficiency?

Prevalence of ACTH Deficiency: how many people are affected worldwide, differences by sex and region, with sources.

Prevalence of ACTH Deficiency

ACTH deficiency is a relatively rare condition characterized by the inadequate production or release of adrenocorticotropic hormone (ACTH) by the pituitary gland. ACTH is responsible for stimulating the production and release of cortisol from the adrenal glands, which plays a crucial role in regulating various bodily functions.


The prevalence of ACTH deficiency varies depending on the population studied and the underlying causes. In general, it is estimated to affect approximately 150 to 280 individuals per million population. However, the true prevalence may be higher as the condition often goes undiagnosed or misdiagnosed due to its nonspecific symptoms.


ACTH deficiency can occur as a result of various factors, including pituitary tumors, pituitary surgery, radiation therapy, autoimmune diseases, genetic disorders, or certain medications. It can present at any age, from infancy to adulthood.


Common symptoms of ACTH deficiency include fatigue, weight loss, low blood pressure, electrolyte imbalances, and decreased tolerance to stress. Prompt diagnosis and treatment are essential to prevent potentially life-threatening adrenal crises.


If you suspect ACTH deficiency or have concerns about your adrenal function, it is important to consult with a healthcare professional for proper evaluation and management.


Author: DiseaseMaps Editorial Team
Reviewed against authoritative medical sources (NIH GARD, Orphanet, OMIM)
Last updated: 2023-07-13
Medical disclaimer: This information does not substitute professional medical advice. Always consult your doctor before making health decisions.
Source: DiseaseMaps.org
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