Short answer · Medically reviewed summary · Last updated: 2026-04-06
The primary ICD-10 code for amyloidosis is E85, while the ICD-9 code is 277.3, though these codes are further sub-classified based on the specific protein involved and the organs affected. Understanding Amyloidosis Coding Because amyloidosis is a complex, systemic group of disorders where misfolded proteins deposit in tissues, medical coding is highly specific to reflect the underlying cause. In the ICD-10-CM system, the E85 category is divided to distinguish between hereditary and non-hereditary forms, as well as localized versus systemic involvement.
3 people with Amyloidosis have shared their first-person experience on this question at DiseaseMaps.
ICD10 code of Amyloidosis and ICD9 code
ICD-10 and ICD-9 codes for Amyloidosis, with classification details for clinicians, coders and patients.
The primary ICD-10 code for amyloidosis is E85, while the ICD-9 code is 277.3, though these codes are further sub-classified based on the specific protein involved and the organs affected.
Understanding Amyloidosis Coding
Because amyloidosis is a complex, systemic group of disorders where misfolded proteins deposit in tissues, medical coding is highly specific to reflect the underlying cause. In the ICD-10-CM system, the E85 category is divided to distinguish between hereditary and non-hereditary forms, as well as localized versus systemic involvement. For example, E85.0 refers to hereditary familial amyloidosis with neuropathy, whereas E85.8 includes other forms of amyloidosis, such as the increasingly recognized wild-type transthyretin amyloidosis (ATTRwt).
For patients and caregivers, seeing these codes on your medical records is common during billing and clinical documentation. It is important to remember that these codes are administrative tools used by healthcare systems to track the prevalence and treatment of amyloidosis. While these numbers are necessary for insurance and research, they do not define your journey or the complexity of the symptoms you may be experiencing.
Navigating Your Medical Documentation
Living with amyloidosis requires coordinated care across multiple specialties, including cardiology, neurology, and hematology. If you notice discrepancies in your medical records regarding your specific ICD code, do not hesitate to ask your specialist for clarification. Understanding how your specific subtype of amyloidosis is coded can help ensure that your care team is aligned on the specific protein precursor, such as light chain (AL) or transthyretin (ATTR), which dictates your therapeutic path. We encourage you to reach out to the DiseaseMaps.org community to share experiences on how these administrative classifications have impacted your access to specialized care and clinical trials.
Medical Disclaimer: This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
References
- NIH Genetic and Rare Diseases Information Center (GARD): Amyloidosis
- Orphanet: Rare disease database for Amyloidosis
- OMIM (Online Mendelian Inheritance in Man): Amyloidosis entry #105210
Posted Jul 11, 2019 by ESPERARE
Posted Jun 3, 2017 by Nancy 2000
Posted Jul 19, 2017 by Phyllis 2000
