Short answer · Medically reviewed summary · Last updated: 2026-04-08

The primary ICD-10 code for Amyotrophic lateral sclerosis (ALS) is G12.21, while the historical ICD-9 code is 335.20. These diagnostic codes are essential for medical billing, clinical documentation, and tracking the prevalence of Amyotrophic lateral sclerosis within global health systems. Why are diagnostic codes like G12.21 important for Amyotrophic lateral sclerosis? In the medical community, diagnostic codes serve as a standardized language to ensure consistent reporting of Amyotrophic lateral sclerosis across clinical settings.

3 people with Amyotrophic lateral sclerosis ALS have shared their first-person experience on this question at DiseaseMaps.

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ICD10 code of Amyotrophic lateral sclerosis ALS and ICD9 code

ICD-10 and ICD-9 codes for Amyotrophic lateral sclerosis ALS, with classification details for clinicians, coders and patients.

ICD9 and ICD10 codes of Amyotrophic lateral sclerosis ALS

The primary ICD-10 code for Amyotrophic lateral sclerosis (ALS) is G12.21, while the historical ICD-9 code is 335.20. These diagnostic codes are essential for medical billing, clinical documentation, and tracking the prevalence of Amyotrophic lateral sclerosis within global health systems.



Why are diagnostic codes like G12.21 important for Amyotrophic lateral sclerosis?


In the medical community, diagnostic codes serve as a standardized language to ensure consistent reporting of Amyotrophic lateral sclerosis across clinical settings. The ICD-10-CM code G12.21 specifically denotes motor neuron disease, which is the umbrella category for ALS. For patients within the DiseaseMaps community—where 333 people with Amyotrophic lateral sclerosis currently share their experiences—these codes are often used to secure insurance coverage for specialized care, assistive technology, and multidisciplinary clinic visits. Accurate coding ensures that your medical records clearly reflect the progressive nature of the condition, which is vital for long-term care planning.



What is the difference between ICD-9 and ICD-10 for ALS?


The transition from ICD-9 to ICD-10 represented a significant expansion in medical classification. While the older ICD-9 code 335.20 was a broader classification for motor neuron disease, the modern ICD-10 system provides more granular detail for Amyotrophic lateral sclerosis. This specificity allows researchers to better analyze epidemiological data, track the effectiveness of interventions, and understand the geographic distribution of Amyotrophic lateral sclerosis globally. By utilizing the correct G12.21 code, physicians ensure that the patient’s diagnosis is recognized by international health standards.



How is a diagnosis of Amyotrophic lateral sclerosis confirmed?


Because there is no single test to diagnose Amyotrophic lateral sclerosis, clinicians rely on the El Escorial criteria. This diagnostic framework involves a clinical examination to document the presence of both upper and lower motor neuron signs. The diagnostic process typically includes:



  • Electromyography (EMG) and Nerve Conduction Studies (NCS): To detect electrical evidence of muscle denervation.

  • Magnetic Resonance Imaging (MRI): To rule out other conditions like cervical spondylotic myelopathy or structural lesions.

  • Laboratory Testing: Blood and urine tests to exclude metabolic or inflammatory mimics of Amyotrophic lateral sclerosis.

  • Genetic Testing: If a family history is present, identifying specific mutations (such as C9orf72, SOD1, or TARDBP) can confirm the diagnosis.



What should you do if you are navigating a new diagnosis?


Receiving a diagnosis of Amyotrophic lateral sclerosis is a life-altering event that requires a multidisciplinary approach. Engaging with a specialized neurologist and a dedicated care team is the most effective way to manage the physical and emotional challenges associated with this condition. The DiseaseMaps platform provides a space to connect with others who understand the unique diagnostic journey of living with Amyotrophic lateral sclerosis.



Next steps



  • Consult a neurologist specializing in neuromuscular disorders to confirm your diagnosis code and discuss a personalized treatment plan.

  • Ensure your medical records accurately reflect your symptoms using the G12.21 code for insurance and disability documentation.

  • Connect with the 333 members of the DiseaseMaps community who are living with Amyotrophic lateral sclerosis to share resources and coping strategies.

  • Reach out to organizations like the ALS Association or the International Alliance of ALS/MND Associations for patient support and clinical trial information.



Medical disclaimer: This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment; always seek the advice of your physician or other qualified health provider with any questions regarding a medical condition.



References



  • NIH Genetic and Rare Diseases Information Center (GARD): Amyotrophic lateral sclerosis.

  • Orphanet: Rare Disease Database, Amyotrophic lateral sclerosis (ORPHA:803).

  • OMIM (Online Mendelian Inheritance in Man): Amyotrophic lateral sclerosis 1 (Entry #105400).

  • World Health Organization: International Classification of Diseases, 10th Revision (ICD-10).

Medical disclaimer: This information does not substitute professional medical advice. Always consult your doctor before making health decisions.
Source: DiseaseMaps.org
4 answers
I would like to thank Ultimate Health Home for reversing my father's Amyotrophic Lateral Sclerosis (ALS). My father’s ALS condition was fast deteriorating before he started on the ALS Herbal medicine treatment from Ultimate Health Home. He was on the treatment for just 6 months and we never thought my father will recover so soon. He has gained some weight in the past months and he is able to walk with no support. You can contact them at [email protected]

Posted Apr 15, 2021 by William 1320
Translated from spanish Improve translation
the CODES are TECHNICAL HEALTH TO CLASSIFY DISEASES

Posted May 25, 2017 by Ricardo 2000
Translated from spanish Improve translation
CIE 10 G 12.2 y ICE 9 335.20

Posted May 27, 2017 by Aranzazú 2060

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