Short answer · Medically reviewed summary · Last updated: 2026-05-08
Castleman disease, also known as giant lymph node hyperplasia or angiofollicular lymph node hyperplasia, is a rare disorder involving the overgrowth of cells in the lymphatic system. While historically referred to by several descriptive names, the medical community now primarily uses Castleman disease to describe the condition, which is further categorized into unicentric and multicentric subtypes. Why does Castleman disease have multiple names? The naming of Castleman disease has evolved since it was first described by Dr.
Castleman disease synonyms
Other names for Castleman disease: synonyms, acronyms and related terms used by doctors and patients.
Castleman disease, also known as giant lymph node hyperplasia or angiofollicular lymph node hyperplasia, is a rare disorder involving the overgrowth of cells in the lymphatic system. While historically referred to by several descriptive names, the medical community now primarily uses Castleman disease to describe the condition, which is further categorized into unicentric and multicentric subtypes.
Why does Castleman disease have multiple names?
The naming of Castleman disease has evolved since it was first described by Dr. Benjamin Castleman in 1954. Early literature frequently used descriptive pathological terms because the underlying cause was not yet understood. As researchers identified distinct clinical presentations, the terminology shifted to reflect these differences, helping clinicians distinguish between localized (unicentric) and systemic (multicentric) forms of Castleman disease.
What are the common synonyms and historical terms?
If you are reviewing older medical records, you may encounter several historical terms or synonyms for Castleman disease. These include:
- Angiofollicular lymph node hyperplasia
- Giant lymph node hyperplasia
- Lymphoid hamartoma
- Angiomatous lymphoid hamartoma
- Follicular lymphoreticuloma
How is the condition classified in medical systems?
Standardized medical systems ensure consistency in global research. In the International Classification of Diseases (ICD-10/11), Castleman disease is categorized under diseases of the blood and blood-forming organs. In the Online Mendelian Inheritance in Man (OMIM) database, it is identified by specific entry numbers related to its genetic and clinical associations. Orphanet, the reference portal for rare diseases, uses the term Castleman disease as the primary label to ensure patients and researchers can access unified clinical guidelines and current trial information.
Which name should patients use?
Medical professionals today almost exclusively use the term Castleman disease. Using this standardized name when searching for information or communicating with specialists will provide you with the most accurate and up-to-date data. Within our community at DiseaseMaps.org, 59 people with Castleman disease have shared their experiences, providing a valuable network for those seeking support under the modern, accepted terminology.
Next steps
- Consult with a hematologist or oncologist who specializes in lymphoproliferative disorders.
- Request your medical records to clarify if your diagnosis is unicentric or multicentric.
- Join the DiseaseMaps.org community to connect with others who have been diagnosed with Castleman disease.
- Review the latest research on the Castleman Disease Collaborative Network (CDCN) website.
Medical Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment.
References
- Orphanet: Castleman disease (ORPHA:1376)
- NIH GARD: Castleman disease
- Castleman Disease Collaborative Network (CDCN)
- OMIM: Castleman disease (Entry #602506)
