Short answer · Medically reviewed summary · Last updated: 2026-05-08
Cyclic Neutropenia is identified by the ICD-10 code D70.4, while under the older ICD-9-CM classification system, it is coded as 288.02. These codes are essential for medical billing and clinical documentation to ensure patients receive appropriate care for this rare condition characterized by periodic drops in neutrophil counts. What is the clinical nature of Cyclic Neutropenia? Cyclic Neutropenia is a rare hematological disorder characterized by regular, recurring fluctuations in the number of circulating neutrophils.
ICD10 code of Cyclic Neutropenia and ICD9 code
ICD-10 and ICD-9 codes for Cyclic Neutropenia, with classification details for clinicians, coders and patients.
Cyclic Neutropenia is identified by the ICD-10 code D70.4, while under the older ICD-9-CM classification system, it is coded as 288.02. These codes are essential for medical billing and clinical documentation to ensure patients receive appropriate care for this rare condition characterized by periodic drops in neutrophil counts.
What is the clinical nature of Cyclic Neutropenia?
Cyclic Neutropenia is a rare hematological disorder characterized by regular, recurring fluctuations in the number of circulating neutrophils. In most patients, these cycles occur every 21 days, typically lasting 3 to 5 days. During these periods of severe neutropenia, individuals with Cyclic Neutropenia are highly susceptible to infections, including fever, oral ulcers, and gingivitis. With 25 community members on DiseaseMaps.org sharing their experiences, we recognize that the severity of these cycles can vary significantly between individuals.
Is Cyclic Neutropenia hereditary?
Yes, Cyclic Neutropenia is typically an autosomal dominant disorder caused by mutations in the ELANE gene, which encodes neutrophil elastase. While it is often inherited, some cases may arise from a new (de novo) mutation. Genetic counseling is highly recommended for families affected by Cyclic Neutropenia to understand the transmission patterns and the 50% recurrence risk for offspring.
How is this condition managed?
Management focuses on reducing the frequency and severity of infections during the neutropenic nadir. Standard clinical approaches include:
- Granulocyte colony-stimulating factor (G-CSF): Daily injections to increase neutrophil counts and shorten the duration of neutropenia.
- Aggressive oral hygiene: Preventing secondary infections caused by mouth ulcers.
- Prompt antibiotic therapy: Managing fever and infections immediately as they arise.
- Regular blood monitoring: Tracking the 21-day cycle to anticipate high-risk periods.
Next steps
- Consult a hematologist or immunologist experienced in primary neutropenic disorders.
- Join the Cyclic Neutropenia community on DiseaseMaps.org to connect with others sharing similar health journeys.
- Maintain a detailed symptom diary to help your physician optimize your G-CSF dosage.
Medical disclaimer: This information is for educational purposes and should not replace professional medical advice, diagnosis, or treatment.
References
- NIH Genetic and Rare Diseases Information Center (GARD): Cyclic Neutropenia
- Orphanet: Neutropenia, cyclic (ORPHA:647)
- OMIM (Online Mendelian Inheritance in Man): Neutropenia, Cyclic (Entry #162800)
- National Organization for Rare Disorders (NORD): Cyclic Neutropenia
