Short answer · Medically reviewed summary · Last updated: 2026-05-08
Factor V deficiency, also known as Owren's disease or parahemophilia, is an inherited condition caused by mutations in the F5 gene. It follows an autosomal recessive inheritance pattern, meaning an individual must inherit two copies of the mutated gene—one from each parent—to manifest symptoms of the disorder. Is Factor V deficiency hereditary? Yes, Factor V deficiency is strictly a hereditary condition, meaning it is passed down through families via genetic material.
Is Factor V Deficiency hereditary?
Is Factor V Deficiency hereditary? The genetic component explained in plain language, reviewed against medical sources, with patient experiences.
Factor V deficiency, also known as Owren's disease or parahemophilia, is an inherited condition caused by mutations in the F5 gene. It follows an autosomal recessive inheritance pattern, meaning an individual must inherit two copies of the mutated gene—one from each parent—to manifest symptoms of the disorder.
Is Factor V deficiency hereditary?
Yes, Factor V deficiency is strictly a hereditary condition, meaning it is passed down through families via genetic material. It is not acquired through lifestyle or environmental factors. Because it is autosomal recessive, most individuals with Factor V deficiency are born to parents who are both asymptomatic carriers, meaning each parent carries one normal gene and one mutated gene.
What is the inheritance risk for children?
When both parents are carriers of the F5 gene mutation, the risk for each pregnancy follows specific statistical probabilities:
- 25% chance the child will inherit two mutated genes and have Factor V deficiency.
- 50% chance the child will be an asymptomatic carrier like the parents.
- 25% chance the child will inherit two normal genes and be neither affected nor a carrier.
Are de novo mutations common in Factor V deficiency?
De novo (spontaneous) mutations that result in clinically significant Factor V deficiency are extremely rare. The vast majority of cases are inherited from parents who carry the trait. Therefore, genetic testing is primarily used to confirm a diagnosis in symptomatic patients or to provide family planning information to relatives.
How does genetic counseling assist families?
Genetic counseling is highly recommended for families affected by Factor V deficiency. A counselor can help map the family history, explain the likelihood of passing the condition to future children, and discuss prenatal diagnostic options. For those planning a pregnancy, testing can determine the carrier status of a partner, which is crucial for understanding the potential health risks for the child.
Next steps
- Consult a hematologist or a clinical geneticist to discuss diagnostic testing and family screening.
- Connect with the 3 members living with Factor V deficiency on DiseaseMaps.org to share experiences.
- Request a referral to a genetic counselor to discuss family planning and inheritance risks.
Medical disclaimer: This content is for informational purposes only and does not constitute medical advice, diagnosis, or treatment; always seek the advice of your physician or other qualified health provider.
References
- NIH Genetic and Rare Diseases Information Center (GARD): Factor V deficiency
- Orphanet: Congenital factor V deficiency
- OMIM (Online Mendelian Inheritance in Man): Coagulation Factor V Deficiency
