Short answer · Medically reviewed summary · Last updated: 2026-05-08
Factor V Deficiency, also known as Owren's disease or parahemophilia, is classified under ICD-10 code D68.2 (Hereditary deficiency of other clotting factors). In the older ICD-9-CM classification system, this condition is identified by code 286.3 (Congenital deficiency of other clotting factors). What exactly is Factor V Deficiency? Factor V Deficiency is an extremely rare autosomal recessive bleeding disorder caused by a mutation in the F5 gene, leading to reduced levels or impaired function of the Factor V protein.
ICD10 code of Factor V Deficiency and ICD9 code
ICD-10 and ICD-9 codes for Factor V Deficiency, with classification details for clinicians, coders and patients.
Factor V Deficiency, also known as Owren's disease or parahemophilia, is classified under ICD-10 code D68.2 (Hereditary deficiency of other clotting factors). In the older ICD-9-CM classification system, this condition is identified by code 286.3 (Congenital deficiency of other clotting factors).
What exactly is Factor V Deficiency?
Factor V Deficiency is an extremely rare autosomal recessive bleeding disorder caused by a mutation in the F5 gene, leading to reduced levels or impaired function of the Factor V protein. This protein is essential for the blood coagulation cascade. Because it is a rare bleeding disorder, clinical presentation varies significantly among individuals, with some experiencing only mild bruising while others face severe, life-threatening hemorrhages.
How is Factor V Deficiency diagnosed?
Diagnosis of Factor V Deficiency typically involves a combination of specialized blood tests. Physicians look for a prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT). A specific factor assay is required to confirm the diagnosis by measuring the precise activity level of the Factor V protein in the plasma.
Is Factor V Deficiency hereditary?
Yes, Factor V Deficiency is inherited in an autosomal recessive pattern. This means an individual must inherit two copies of the mutated F5 gene—one from each parent—to manifest the clinical symptoms of the disease. Carriers (those with one mutated gene) typically remain asymptomatic, which can make tracking the family history of Factor V Deficiency challenging.
What are the common clinical symptoms?
While severity varies, individuals living with Factor V Deficiency often report the following symptoms:
- Easy bruising and frequent nosebleeds (epistaxis).
- Prolonged bleeding after surgical procedures or dental extractions.
- Menorrhagia (abnormally heavy menstrual bleeding).
- Intracranial or gastrointestinal hemorrhage in severe cases (affecting approximately 1 in 1,000,000 people).
Next steps
- Consult a hematologist specializing in rare coagulation disorders to discuss an individualized management plan.
- Connect with others at DiseaseMaps.org to share experiences with the 3 community members currently registered.
- Maintain a detailed medical alert card describing your specific Factor V levels for emergency situations.
Medical disclaimer: This content is for informational purposes only and does not constitute medical advice, diagnosis, or treatment; always seek the advice of your physician or other qualified health provider with any questions regarding a medical condition.
References
- Orphanet: Factor V deficiency (ORPHA774).
- NIH Genetic and Rare Diseases Information Center (GARD): Parahemophilia.
- OMIM (Online Mendelian Inheritance in Man): Factor V Deficiency (#227400).
- World Federation of Hemophilia (WFH): Rare Bleeding Disorders guidelines.
