Short answer · Medically reviewed summary · Last updated: 2026-04-07
The ICD-10-CM code for Factor V Leiden is D68.59, which covers other primary thrombophilia, while the legacy ICD-9-CM code used for this condition was 289.81. As a hematologist, I recognize that receiving a diagnosis of Factor V Leiden can be an overwhelming experience, even though the condition itself often remains asymptomatic until a thrombotic event occurs. Factor V Leiden is a genetic mutation that causes a form of inherited thrombophilia, increasing the risk of venous thromboembolism (VTE).
3 people with Factor V Leiden have shared their first-person experience on this question at DiseaseMaps.
ICD10 code of Factor V Leiden and ICD9 code
ICD-10 and ICD-9 codes for Factor V Leiden, with classification details for clinicians, coders and patients.
The ICD-10-CM code for Factor V Leiden is D68.59, which covers other primary thrombophilia, while the legacy ICD-9-CM code used for this condition was 289.81.
As a hematologist, I recognize that receiving a diagnosis of Factor V Leiden can be an overwhelming experience, even though the condition itself often remains asymptomatic until a thrombotic event occurs. Factor V Leiden is a genetic mutation that causes a form of inherited thrombophilia, increasing the risk of venous thromboembolism (VTE). Because Factor V Leiden does not typically present with outward physical signs, the diagnosis is often made only after a patient experiences a deep vein thrombosis (DVT) or a pulmonary embolism (PE).
Understanding the Diagnostic Codes
In clinical practice, medical coding is essential for insurance billing and tracking the prevalence of Factor V Leiden within health systems. While the ICD-10 code D68.59 is the standard for primary thrombophilia, clinicians sometimes also document the specific manifestation of the disease, such as a DVT or PE, to ensure appropriate treatment pathways—like anticoagulation therapy—are covered and prioritized.
Living with the Diagnosis
From a clinical perspective, it is important to remember that having Factor V Leiden does not mean you will inevitably experience a clot. Many individuals with this mutation live their entire lives without a single thrombotic event. However, understanding your specific risk factors—such as surgery, pregnancy, or prolonged immobilization—is vital. If you are part of the 509 members in the DiseaseMaps community, you likely know that managing this condition is about proactive awareness rather than constant fear. We encourage you to work closely with a hematologist to determine if prophylactic measures, such as compression stockings or temporary anticoagulation during high-risk situations, are necessary for your specific clinical profile.
Medical Disclaimer: This information is for educational purposes only and does not constitute formal medical advice, diagnosis, or treatment. Always seek the advice of your hematologist or another qualified health provider with any questions you may have regarding your medical condition.
References
- NIH Genetic and Rare Diseases Information Center (GARD): Factor V Leiden Thrombophilia
- Orphanet: Factor V Leiden
- OMIM (Online Mendelian Inheritance in Man): Factor V; F5
D68.52 is a billable ICD code used to specify a diagnosis of prothrombin gene mutation
ICD-10 Code D68.51, Activated protein C resistance.
D68.59 is a billable ICD code used to specify a diagnosis of other primary thrombophilia.
(To the best of my knowledge)
Posted Sep 1, 2017 by Stacy 2650
ICD-9-CM code of Factor V Leiden is 289.81
Posted Dec 28, 2017 by Barbara 4050
Posted Dec 28, 2017 by Crystal 700
