Factor five Leiden is now the most common hereditary coagulation disorder in the United States. It is found in 5% of Caucasians and 1.2% of the Afro-American population. FVL has its lowest frequencies among the Hispanic Americans, African Americans and almost never with indigenous people from Asia, America and Australia. The highest reports are seen in Europeans, some areas report as high as 15% of the population as carriers. FVL is autosomal dominant with inheritance. This means that it affects men and women equally and passes from generation to generation.