Well, how you handle FD may or may not cause depression. It affects my mood whenever I am in pain. It makes me more moody than usual. The hardest, so far, to deal with is when I have a migraine and body pain and I need to do something, like doing school works as I am an honor student, and accidents. Frustrations will always be there, sometimes questioning why me out of everyone. But FD made me stronger, made the person I am today, so I can have FD all over again.