Short answer · Medically reviewed summary · Last updated: 2023-07-13
Glucose-Galactose Malabsorption (GGM) is a rare genetic disorder that affects the ability of the small intestine to absorb glucose and galactose, two types of sugars found in many foods. It is not a contagious condition, meaning it cannot be transmitted from one person to another. GGM is caused by mutations in the SGLT1 gene, which is responsible for producing a protein called sodium-glucose cotransporter 1.
Glucose-Galactose Malabsorption (GGM) is a rare genetic disorder that affects the ability of the small intestine to absorb glucose and galactose, two types of sugars found in many foods. It is not a contagious condition, meaning it cannot be transmitted from one person to another.
GGM is caused by mutations in the SGLT1 gene, which is responsible for producing a protein called sodium-glucose cotransporter 1. This protein plays a crucial role in the absorption of glucose and galactose from the intestine into the bloodstream. In individuals with GGM, this protein is either absent or not functioning properly, leading to malabsorption of these sugars.
The primary symptoms of GGM include diarrhea, abdominal pain, bloating, and failure to thrive, especially in infants. These symptoms typically appear shortly after birth or when an affected individual starts consuming foods containing glucose and galactose.
It is important to note that GGM is a genetic disorder and not an infectious disease. It is inherited in an autosomal recessive manner, meaning that both parents must carry a copy of the mutated gene for their child to be affected. Genetic counseling can help individuals understand their risk of passing on the condition to their children.
Treatment for GGM involves avoiding foods that contain glucose and galactose. Individuals with GGM may need to follow a strict diet that excludes certain fruits, dairy products, and other foods high in these sugars. They may also require specialized formulas or supplements to ensure proper nutrition.