Short answer · Medically reviewed summary · Last updated: 2026-05-08
Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) is classified under ICD-10 code G60.0 (Hereditary motor and sensory neuropathy) and was historically categorized under ICD-9 code 356.2. These codes are used for medical billing and administrative tracking for individuals living with this rare peripheral nerve disorder. What is the genetic cause of HNPP? Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) is a genetic condition caused by a deletion of the PMP22 gene on chromosome 17p12.
1 people with Hereditary Neuropathy With Liability To Pressure Palsies HNPP have shared their first-person experience on this question at DiseaseMaps.
ICD10 code of Hereditary Neuropathy With Liability To Pressure Palsies HNPP and ICD9 code
ICD-10 and ICD-9 codes for Hereditary Neuropathy With Liability To Pressure Palsies HNPP, with classification details for clinicians, coders and patients.
Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) is classified under ICD-10 code G60.0 (Hereditary motor and sensory neuropathy) and was historically categorized under ICD-9 code 356.2. These codes are used for medical billing and administrative tracking for individuals living with this rare peripheral nerve disorder.
What is the genetic cause of HNPP?
Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) is a genetic condition caused by a deletion of the PMP22 gene on chromosome 17p12. This deletion leads to the production of insufficient peripheral myelin protein 22, which causes the nerve fibers to become abnormally sensitive to compression, stretching, or minor trauma. Understanding this genetic foundation is essential for diagnosis, as Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) typically follows an autosomal dominant inheritance pattern.
How does HNPP present clinically?
Patients with Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) often experience episodic nerve palsies or sensory loss. Symptoms are frequently triggered by minor physical stress, such as leaning on an elbow or repetitive movements. Common clinical features include:
- Transient, painless focal motor weakness (e.g., foot drop or wrist drop).
- Sensory disturbances, including numbness or paresthesia in the affected limb.
- Slowed nerve conduction velocities detected during electromyography (EMG).
- Recovery periods that can range from hours to several months.
Is there a community for those living with HNPP?
Navigating a rare diagnosis can feel isolating, but you are not alone. Currently, 89 people with Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) have joined the DiseaseMaps.org community to share their experiences and support one another. Connecting with others who understand the day-to-day management of Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) can be a vital part of your care journey.
Next steps
- Consult with a neurologist or clinical geneticist to confirm your diagnosis through genetic testing.
- Practice "nerve-sparing" habits, such as avoiding crossing your legs or leaning on elbows for extended periods.
- Join the Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) community at DiseaseMaps.org to connect with peers.
- Work with a physical therapist to maintain muscle strength and learn protective strategies for vulnerable nerves.
Medical disclaimer: This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment; always seek the advice of your physician regarding a medical condition.
References
- NIH Genetic and Rare Diseases Information Center (GARD): HNPP entry.
- Orphanet: Rare disease database, ORPHA:647.
- OMIM (Online Mendelian Inheritance in Man): Entry #162500.
- Neuropathy Commons (Harvard Medical School): Information on hereditary neuropathies.
Posted Jan 3, 2020 by Patricia 2600
