As a chronic pain condition with unknown cause and difficult management Intracranial Hypertension has a high association with depression. Without effective management, intracranial hypertension can severely limit the quality of life, and medications used to treat IH can increase fatigue, cognitive impairments and mental health, which further increases the functional disability of IH. This can increase the mood affect of the individual, and often results in severe depression. Individuals on Topiramate must be monitored for additional side effect for suicidality.