Depending on the symptoms of each one. I've always had some symptoms but that the treatment by general practitioners always depreciated, but that after the appearance of some stains (which I thought inestetico) I went to a dermatologist who collected some of the spots to biopsy the skin and after this result was the analysis sanguineas, biopsy bone marrow, and mielograma, ultrasounds and x-rays to the complete skeleton, as well as bone densitometry bone.