Short answer · Medically reviewed summary · Last updated: 2023-07-13
Mal de Meleda is a rare genetic disorder characterized by thickening of the skin on the palms of the hands and soles of the feet. It is inherited in an autosomal recessive manner, meaning that both parents must carry a copy of the mutated gene for their child to be affected. The prevalence of Mal de Meleda is extremely low, with only a few hundred cases reported worldwide.
What is the prevalence of Mal de Meleda?
Prevalence of Mal de Meleda: how many people are affected worldwide, differences by sex and region, with sources.
Mal de Meleda is a rare genetic disorder characterized by thickening of the skin on the palms of the hands and soles of the feet. It is inherited in an autosomal recessive manner, meaning that both parents must carry a copy of the mutated gene for their child to be affected.
The prevalence of Mal de Meleda is extremely low, with only a few hundred cases reported worldwide. It is most commonly found in individuals of Mediterranean descent, particularly in the island of Meleda in Croatia, from which the disorder gets its name.
Due to its rarity, the exact prevalence of Mal de Meleda is difficult to determine. However, it is estimated to affect approximately 1 in every 100,000 to 200,000 individuals globally. The disorder typically presents in early childhood and persists throughout life, causing significant physical and functional impairment.
Although there is currently no cure for Mal de Meleda, treatment focuses on managing symptoms and preventing complications. This may include regular moisturizing, keratolytic agents, and physical therapy to improve hand function.
