Muckle-Wells syndrome is a disorder characterized by periodic episodes of skin rash, fever, and joint pain arise spontaneously or can be triggered by cold, heat, fatigue, or other stresses. Progressive hearing loss and kidney damage as the most severe that can alter your life. Hearing loss caused by progressive nerve damage (sensorineural deafness), Chronic Hives, and High fevers, Papilledma, abdominal pain, infertility, muscle and joint pain/popping, Chronic fatigue, conjunctivitis are all symptoms of Muckle Wells Syndrome.